Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery

Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery

Author: Singh, Ajeet

Publisher: IGI Global

ISBN: 9781668451304

Category: Science

Page: 754

View: 293

A great deal of interest has been generated recently in the isolation, characterization, and biological activity of phytochemicals. Phytochemicals have the potential to enhance pharmaceuticals and drug discovery. As such, there is an urgent need for current research in the global scope of phytochemicals including the chemical and physical characteristics, analytical procedures, biological activity, safety, and industrial applications. The Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery examines the applications of bioactive molecules from a health perspective, examining the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany and medicinal properties. Moreover, it presents a novel dietary approach for human disease management. Covering topics such as computer-aided drug design, government regulation, and medicinal plant taxonomy, this major reference work is beneficial to pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.

Phytochemicals As Lead Compounds for New Drug Discovery

Phytochemicals As Lead Compounds for New Drug Discovery

Author: Chukwuebuka Egbuna

Publisher:

ISBN: 0128178906

Category: Drug development

Page: 378

View: 821

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Phytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery

Author: Chukwuebuka Egbuna

Publisher: Elsevier

ISBN: 9780128178911

Category: Science

Page: 378

View: 877

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Bioactive Phytochemicals

Bioactive Phytochemicals

Author: Javed Ahamad

Publisher:

ISBN: 9811464472

Category:

Page: 238

View: 308

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Herbal Biomolecules in Healthcare Applications

Herbal Biomolecules in Healthcare Applications

Author: Subhash C. Mandal

Publisher: Academic Press

ISBN: 9780323900805

Category: Business & Economics

Page: 750

View: 706

Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful. Provides a study of different type of biomolecules from herbal extracts and their bioactivities as well as their application in the healthcare industry Contributions by global leaders and experts from academia, industry and regulatory agencies, who have been considered as pioneers in the application of herbal biomolecules in the diverse healthcare fields Includes updated literature review along with practical examples and research case studies

The Phytochemical and Pharmacological Aspects of Ethnomedicinal Plants

The Phytochemical and Pharmacological Aspects of Ethnomedicinal Plants

Author: V. R. Mohan

Publisher: CRC Press

ISBN: 9781000206883

Category: Science

Page: 486

View: 804

This book addresses the resurgence of interest in the rediscovery of ethnomedicinal plants as a source of potential ethnomedicines. In the 21st century, the pharmacological effects of medicinal plants are considered to have a promising future as drugs and medicines for the management of healthcare. Considering the extremely high cost and length of time needed for the development of new drugs, as well as the high drug attrition rate, pharmaceutical companies and researchers continue to explore new ways for drug R&D and focus more attention on the benefits of ethnomedical plants as a source of new compounds for drugs. The research provided in this timely volume examines the development and characterization of new natural drugs from medicinal plants with the aid of better screening methods. The chapters survey specific medicinal plant species and describe the characteristics of each, how the plants work, and their applications for healthcare. The authors provide research on plants from Western Ghats and adjoining areas for ethnomedicinal investigation because this area is very rich in phytodiversity and tribal traditions in phytotherapy and the plants surveyed have applications beyond this region. This book is a valuable medical compendium of plants and is intended as a guide and reference resource for professionals in the field. It reviews the current status of ethnomedicinal plants research in light of the surge in the demand for herbal medicine as a future source of new therapeutics.

Isolation, Characterization, and Therapeutic Applications of Natural Bioactive Compounds

Isolation, Characterization, and Therapeutic Applications of Natural Bioactive Compounds

Author: Singh, Ajeet

Publisher: IGI Global

ISBN: 9781668473382

Category: Medical

Page: 420

View: 871

Natural products have historically been key to drug discovery and therapeutic applications throughout many societies. In the modern era, natural bioactive compounds can be isolated, and their effects can be further studied for more successful outcomes. It is essential to study these natural bioactive compounds to enhance pharmaceuticals and drug discovery. Isolation, Characterization, and Therapeutic Applications of Natural Bioactive Compounds examines the applications of natural bioactive compounds from a health perspective. It discusses medicinal and therapeutic applications of natural bioactive molecules as well as the biological activities of different natural products and their properties. Covering topics such as drug discovery, government regulations, and phytochemical extraction, this premier reference source is an excellent resource for pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.

Handbook of Plant Food Phytochemicals

Handbook of Plant Food Phytochemicals

Author: Brijesh K. Tiwari

Publisher: John Wiley & Sons

ISBN: 9781118464687

Category: Technology & Engineering

Page: 528

View: 885

Phytochemicals are plant derived chemicals which may bestowhealth benefits when consumed, whether medicinally or as part of abalanced diet. Given that plant foods are a major component of mostdiets worldwide, it is unsurprising that these foods represent thegreatest source of phytochemicals for most people. Yet it is onlyrelatively recently that due recognition has been given to theimportance of phytochemicals in maintaining our health. Newevidence for the role of specific plant food phytochemicals inprotecting against the onset of diseases such as cancers and heartdisease is continually being put forward. The increasing awarenessof consumers of the link between diet and health has exponentiallyincreased the number of scientific studies into the biologicaleffects of these substances. The Handbook of Plant Food Phytochemicals provides acomprehensive overview of the occurrence, significance and factorseffecting phytochemicals in plant foods. A key of objective of thebook is to critically evaluate these aspects. Evaluation ofthe evidence for and against the quantifiable health benefits beingimparted as expressed in terms of the reduction in the risk ofdisease conferred through the consumption of foods that are rich inphytochemicals. With world-leading editors and contributors, the Handbook ofPlant Food Phytochemicals is an invaluable, cutting-edgeresource for food scientists, nutritionists and plant biochemists.It covers the processing techniques aimed at the production ofphytochemical-rich foods which can have a role indisease-prevention, making it ideal for both the food industry andthose who are researching the health benefits of particular foods.Lecturers and advanced students will find it a helpful and readableguide to a constantly expanding subject area.

Anticancer plants: Properties and Application

Anticancer plants: Properties and Application

Author: Mohd Sayeed Akhtar

Publisher: Springer

ISBN: 9789811085482

Category: Science

Page: 582

View: 806

Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities. Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.

Phytochemicals in Health and Disease

Phytochemicals in Health and Disease

Author: Yongping Bao

Publisher: CRC Press

ISBN: 9780824751876

Category: Medical

Page: 328

View: 366

"... well-written and the content is clearly presented. ... There are plentiful figures and tables, which are effectively labeled and adequately support the content. ...highly recommended for academic and special libraries. ...effectively presents current research on phytochemicals in a readable manner." - E-Streams "This landmark volume shows how far the field has advanced ... . This important volume is filled with reports on what the editors term as the 'new era' in the study of phytochemicals, in which we move from the 'eat more vegetable and fruit' admonition to more detailed information on the biology, molecular biology, regulatory function, and role in human health of phytochemicals. ... All workers in phytochemicals should get themselves a copy of this valuable book."

Advances in Nanotechnology-Based Drug Delivery Systems

Advances in Nanotechnology-Based Drug Delivery Systems

Author: Anupam Das Talukdar

Publisher: Elsevier

ISBN: 9780323904148

Category: Technology & Engineering

Page: 670

View: 766

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more