Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented is scattered, therefore becoming difficult for readers and researchers to digest in a concise manner. This gathering of information will help readers easily comprehend the subject matter. Focuses on biopolysaccharide-based, distinct approaches for drug delivery applications Illustrates new concepts and highlights future scope for clinical development Provides comprehensive, up-to-date information on different aspects of drug delivery technology
This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.
Natural Polysaccharides in Drug Delivery and Biomedical Applications provides a fundamental overview of natural polysaccharides, their sources, extraction methodologies, and characterizations. It covers specific natural polysaccharides and their effective application in drug delivery and biomedical use. Additionally, chapters in the book discuss key topics including the sources and extraction methodologies of natural polysaccharides, their role in tissue engineering applications, polysaccharide-based nanoparticles in biomedical applications, and their role in the delivery of anticancer drugs. Written by industry leaders and edited by experts, this book emphasizes recent advances made in the field. Natural Polysaccharides in Drug Delivery and Biomedical Applications provides academics, researchers, and pharmaceutical health care professionals with a comprehensive book on polysaccharides in pharmaceutical delivery process. Provides fundamental concepts of natural polysaccharides as it applies to the pharmaceutical, biomedical, and biotechnology industries Includes contributions from global leaders and experts from academia, industry, and regulatory agencies in the application of natural polysaccharides in pharmaceutical products and biomedical utilization Offers practical examples, illustrations, chemical structures, and research case studies to help explain natural polysaccharides concepts in drug delivery and biomedical applications
Doctoral Thesis / Dissertation from the year 2022 in the subject Chemistry - Other, , language: English, abstract: The title of this thesis “Synthesis and Characterization of Drug Carrier Based on Polysaccharides” clearly reflects the objective, which is an approach towards preparation of excipients, defined as ‘the substance used as a medium for giving a medicament’, that is to say with simply the functions of an inert support of the active principle or principles. Okra gum, obtained from the fruits of Hibiscus esculents, is a polysaccharide consisting of D-galactose, L-rhamnose and L-galacturonic acid. It is used as a binder. In studies okra gum has been evaluated as a binder in paracetamol tablet formulations. These formulations containing okra gum as a binder showed a faster onset and higher amount of plastic deformation than those containing gelatin. The crushing strength and disintegration times of the tablets increased with higher binder concentration, while their friability decreased. Although gelatin produced four tablets with higher crushing strength, okra gum produced tablets with longer disintegration times than those containing gelatin. It was finally concluded from the results that okra gum may be a useful hydrophilic matrixing agent in sustained drug delivery system. Various strategies were developed in order to overcome these issues, offering the opportunity to tailor the physical and chemical properties of okra gum thus yielding materials that may find a wide range of applications. Extraction and purification of okra gum was carried out from okra pods. Followed by carboxymethylated and phosphorylation of extracted okra gum, which was carried out along with optimization of reaction parameter of the primary derivatives that is carboxymethylated okra gum and hydroxyl propyl okra phosphate, followed by drug carriers preparation. By the second modification carboxymethylated okra gum and hydroxyl propyl okra phosphate were carried out by cross linking acrylic acid, N, N-methylene acryl amide, hydroxyethyl methacrylate (HEMA) respectively synthesized cross-linked polymer were further investigated as drug carriers by formulating as tablet for sustained drug release. The drug release of different formulations were measured in relation to time and also compared with the standard drugs. Further mathematical modeling was implemented to know the order of release behavior of formulated tables.
Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications. The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery. Provides methodologies for the design, development and selection of tailor-made, natural polysaccharides in drug delivery for particular therapeutic applications Includes illustrations that demonstrate the mechanism of biological interaction of tailor-made polysaccharides Discusses the regulatory aspects and demonstrates the clinical efficacy of tailor-made polysaccharides
Recent advances in nanotechnology have offered a wealth of new opportunities for the design of new therapy of cancer creating new drug delivery systems. It has been possible to produce nanoparticles, in particular polysaccharide-based ones, to allow the site-specific delivery of drugs and to improve the pharmacokinetic profile of numerous compounds. Throughout this work, the system of chitosan (CS)-based nanocarriers produced by coacervation with gum arabic (GA) is presented. The main experiments were focused on the encapsulation of bortezomib (BTZ) and Gold nanoparticles (GoldNP) in the CS/GA system. Completing this work, chemopreventive agents were encapsulated in the same system; catechins (EGCG) and vitamin D; accompanied by Gold nanoparticles too. All the different produced nanoparticles produced were within the size range of 200-400 nm, presenting a low polydispersity index, a positive zeta potential and a spherical shape. The different formulations attained a medium bortezomib encapsulation efficiency of 61%, a EGCG of 40%, a vitamin D of 83% and a Gold nanoparticles encapsulation efficiency of nearly 100%. The encapsulation efficiency was increased for bortezomib, EGCG and vitamin D when the particles were coated with polysorbate 80 which acted as a stabilizing agent. Studies of release for bortezomib and Gold nanoparticles system were carried in water and PBS, showing a biphasic pattern with an initial burst, attributed to the entrapped and surface adsorbed drug, followed by slower release. In water, not all release from nanoparticles was appreciated after long time, besides in PBS it was noted that the nanoparticles were biodegradable. In addition, bortezomib-loaded nanoparticles were tested by in vitro cytotoxic studies. The cytotoxic effect was studied in cancer pancreatic cell line compared to normal pancreatic cell line. They have shown how less concentration of encapsulated bortezomib was needed to have the same effect as free bortezomib in cancer cells. Furthermore, encapsulated bortezomib just inhibited the cell growth as opposed to death of cells produced by free bortezomib, at higher concentrations. According to the results, it is possible to conclude that bortezomib and GoldNP CS/GA nanoparticles is a future alternative to replace the treatment with bortezomib of tumors. Continuing the work with encapsulated EGCG and vitamin D showed also promising results.
Over the last decades we have seen the pharmaceutical industry grow at a tremendous rate. Along with the discoveries of drugs with novel and peculiar properties, the need for novel materials and methods to deliver them energized the field of drug delivery creating new opportunities for material scientists. Among those materials, the pharmaceutical industry has since the beginning relied on cellulose, the most abundant natural polymer on earth. Nowadays, many polysaccharides are used, modified and transformed to serve the pharmaceutical needs either as solubilizers, adhesives, carriers or active substances themselves. This book covers many of the polysaccharides used in the field, their sources, properties, preparation and mechanism of action
Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. Provides a single source on the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields Includes high quality illustrations, along with practical examples and research case studies Contains contributions by global leaders and experts from academia, industry and regulatory agencies who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields
This volume provides a thorough insight into the chemistry and mechanism of ionic gelations of various ionic biopolysaccharides, like alginate, gellan gum, pectin, chitosan, carboxymethyl cellulose, etc., and the applications of various ionically gelled biopolysaccharides in drug delivery fields, with chapters emphasizing the recent advances in the field by the experts. This book will be of interest to graduate students and academic and industry researchers from pharmacy, biotechnology, bioengineering, biomedical and material sciences fields.
This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.
Tailor-Made Polysaccharides in Biomedical Applications provides extensive details on all the vital precepts, basics, and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industries. This information provides readers with the foundation for understanding and developing high-quality products. The utilization of natural polymeric excipients in numerous healthcare applications demands the replacement of the synthetic polymers with natural polymers. Natural polymers are superior in terms of biocompatibility, biodegradability, economic extraction, and ready availability. Natural polymers are especially useful in that they are a renewable source of raw materials, as long as they are grown sustainably. Among these natural polymers, polysaccharides are considered as excellent excipients because they are nontoxic, stable, and biodegradable. Several research innovations have been carried out using polysaccharides in drug delivery applications. This book offers a comprehensive resource to understand the potential of these materials in forming new drug delivery methods. It will be useful to biomedical researchers, chemical engineers, regulatory scientists, and students who are actively involved in developing pharmaceutical products for biomedical applications by using tailor-made polysaccharides. Provides methodology for the design, development, and selection of tailor-made polysaccharides in biomedical applications, including for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of tailor-made polysaccharides Discusses the regulatory aspects and demonstrates the clinical efficacy of tailor-made polysaccharides
Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan
