Sample Sizes for Clinical, Laboratory and Epidemiology Studies

Sample Sizes for Clinical, Laboratory and Epidemiology Studies

Author: David Machin

Publisher: John Wiley & Sons

ISBN: 9781118874943

Category: Medical

Page: 406

View: 501

An authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studies Now in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studiesincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed. This revised fourth edition: Offers the only text available to include sample size software for use in designing and planning clinical studies Presents new and extended chapters with many additional and refreshed examples Includes clear explanations of the principles and methodologies involved with relevant practical examples Makes clear a complex but vital topic that is designed to ensure valid methodology and publishable results Contains guidance from an internationally recognised team of medical statistics experts Written for medical researchers from all specialities and medical statisticians, Sample Sizes for Clinical, Laboratory and EpidemiologyStudies offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.

Psychosomatic Medicine

Psychosomatic Medicine

Author: Ignacio Jáuregui-Lobera

Publisher: BoD – Books on Demand

ISBN: 9781839682322

Category: Medical

Page: 212

View: 145

Modern psychosomatic medicine is a comprehensive framework for a holistic (biopsychosocial) perspective of illnesses and patient care. It highlights the influence of psychosocial factors on health, the interaction between psychosocial and biological factors in the course and outcome of diseases, and a whole perspective with respect to treatments. This book discusses holistic approaches to both organic and psychopathological diseases. Over three sections, authors address psychosomatic approaches to fibromyalgia, palliative care, anxiety and depression, obesity, and traumatic stress disorders.

Randomised Clinical Trials

Randomised Clinical Trials

Author: David Machin

Publisher: John Wiley & Sons

ISBN: 9781119524670

Category: Medical

Page: 560

View: 838

Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process. This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book: Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced Features several new chapters, updated case studies and examples, and references to changes in regulations Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure Covers paired trial designs and trials with more than two interventions Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.

Applied Statistical Considerations for Clinical Researchers

Applied Statistical Considerations for Clinical Researchers

Author: David Culliford

Publisher: Springer Nature

ISBN: 9783030874100

Category: Medical

Page: 241

View: 107

This essential book details intermediate-level statistical methods and frameworks for the clinician and medical researcher with an elementary grasp of health statistics and focuses on selecting the appropriate statistical method for many scenarios. Detailed evaluation of various methodologies familiarizes readers with the available techniques and equips them with the tools to select the best from a range of options. The inclusion of a hypothetical case study between a clinician and statistician charting the conception of the research idea through to results dissemination enables the reader to understand how to apply the concepts covered into their day-to-day clinical practice. Applied Statistical Considerations for Clinical Researchers focuses on how clinicians can approach statistical issues when confronted with a medical research problem by considering the data structure, how this relates to their study's aims and any potential knock-on effects relating to the evidence required to make correct clinical decisions. It covers the application of intermediate-level techniques in health statistics making it an ideal resource for the clinician seeking an up-to-date resource on the topic.

The Design of Studies for Medical Research

The Design of Studies for Medical Research

Author: David Machin

Publisher: John Wiley & Sons

ISBN: UOM:39015060576892

Category: Medical

Page: 274

View: 897

"This book is for anyone working in medical research, from the laboratory through to general practice and public health. It will be ideal for anyone embarking upon research for the first time or submitting a research proposal for funding, but is of relevance to all health and allied health professionals."--BOOK JACKET.

Factbook

Factbook

Author:

Publisher:

ISBN: MINN:31951D02942180M

Category:

Page: 338

View: 918